Comparative Study between Febuxostat and Allupurinol based on Safety and Urate-Lowering Efficacy in Gout Patients of Indian Population

Gout is a form of arthritis with a documented history spanning several thousands of years. Observed by the ancient Egyptian medical practitioner Imhotep as early as 2640BCE, it was also described several centuries later by the Greek physician Hippocrates (400BCE), the father of modern medicine, who referred to it as podagra, or “the unwalkable disease”. Gout represents the most frequent inflammatory joint disease in the general population 1, and it largely contributes to healthcare burden (Smith et al., 2014). Monosodium urate deposition due to longstanding hyperuricemia leading to urate crystal formation in tissues represents the International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 10 (2016) pp. 801-815 Journal homepage: http://www.ijcmas.com